Grey wolf genomic history reveals a dual ancestry of dogs – Nature

Sampling, DNA preparation and sequencing Stockholm Samples LOW002, LOW003, LOW006, LOW007, LOW008 and PON012 were processed at the Archaeological Research Laboratory at Stockholm University, Sweden, following methods previously described8. In brief, this involved extracting DNA by incubating the bone powder for 24 h at 37 °C in 1.5 ml of digestion buffer (0.45 M EDTA (pH 8.0) and 0.25 mg ml–1 proteinase … Read more

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo – Nature Metabolism

Halliwell, B. & Gutteridge J. M. C. Free Radicals in Biology and Medicine 5th edn (Oxford Univ. Press, 2015). Sies, H. et al. Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology. Nat. Rev. Mol. Cell Biol. (2022). Forman, H. J. & Zhang, H. Targeting oxidative stress in disease: promise and … Read more

Mechanism of replication origin melting nucleated by CMG helicase assembly – Nature

Cloning, expression and purification ORC, Cdc6, Mcm2–7–Cdt1, DDK, CDK, Sld2, Sld3–Sld7, Cdc45, Dpb11, Pol ε, Pol ε exo-, Pol α, TopoI, Mcm10 and yeast histone octamer were purified on the basis of previously established protocols1,11,24,33,48,49,50,51. Cloning, expression and purification of Mcm2–7–Cdt1 mutants Designed DNA fragments (Supplementary Table 1) were subcloned from pMA vectors (Supplementary Table … Read more

Structural basis of NPR1 in activating plant immunity – Nature

Delaney, T. P., Friedrich, L. & Ryals, J. A. Arabidopsis signal transduction mutant defective in chemically and biologically induced disease resistance. Proc. Natl Acad. Sci. USA 92, 6602–6606 (1995). ADS  CAS  PubMed  PubMed Central  Article  Google Scholar  Shah, J., Tsui, F. & Klessig, D. F. Characterization of a salicylic acid-insensitive mutant (sai1) of Arabidopsis thaliana, … Read more

Single electrons on solid neon as a solid-state qubit platform – Nature

Ladd, T. D. et al. Quantum computers. Nature 464, 45–53 (2010). ADS  CAS  PubMed  Google Scholar  Popkin, G. Quest for qubits. Science 354, 1090–1093 (2016). ADS  MathSciNet  CAS  PubMed  MATH  Google Scholar  de Leon, N. P. et al. Materials challenges and opportunities for quantum computing hardware. Science 372, 253 (2021). Google Scholar  Hanson, R., Kouwenhoven, … Read more

New insights into the genetic etiology of Alzheimer’s disease and related dementias – Nature Genetics

Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France Céline Bellenguez, Benjamin Grenier-Boley, Vincent Damotte, Marcos R. Costa, Julien Chapuis, R. Pineda-Sánchez, Nathalie Fievet, Hieab Adams, Philippe Amouyel & Jean-Charles Lambert Complex Genetics of Alzheimer’s Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium Fahri Küçükali, Christine Van Broeckhoven, Jasper Van Dongen & Kristel … Read more

Anatomic position determines oncogenic specificity in melanoma – Nature

Tang, J. et al. The genomic landscapes of individual melanocytes from human skin. Nature 586, 600–605 (2020). ADS  CAS  PubMed  PubMed Central  Google Scholar  Fowler, J. C. et al. Selection of oncogenic mutant clones in normal human skin varies with body site. Cancer Discov. 11, 340–361 (2020). PubMed  PubMed Central  Google Scholar  Reed, R. In … Read more

‘Informational simplicity’ may explain why nature favors symmetry

Informational simplicity may explain why nature favors symmetry

In biology, symmetry is typically the rule rather than the exception. Our bodies have left and right halves, starfish radiate from a central point and even trees, though not largely symmetrical, still produce symmetrical flowers. In fact, asymmetry in biology seems quite rare by comparison. Does this mean that evolution has a preference for symmetry? … Read more

Life’s Preference for Symmetry Is Like ‘A New Law of Nature’

Lifes Preference for Symmetry Is Like ‘A New Law of

Symmetry runs rampant in nature. It’s present wherever mirror images are repeated, like in the right and left halves of elephants or butterflies, or in the repeating patterns of flower petals and starfish arms around a central point. It’s even hiding in the structures of tiny things like proteins and RNA. While asymmetry certainly exists … Read more

Subaqueous foraging among carnivorous dinosaurs – Nature

Kelley, N. P. & Pyenson, N. D. Evolutionary innovation and ecology in marine tetrapods from the Triassic to the Anthropocene. Science 348, aaa3716 (2015). PubMed  Google Scholar  Gutarra, S. & Rahman, I. A. The locomotion of extinct secondarily aquatic tetrapods. Biol. Rev. 97, 67–98 (2022). PubMed  Google Scholar  Owen, R. A description of a portion … Read more